Astrocyte inactivation with fluorocitrate blocks the pro-motility effects of glucoprivation. Thus, it appears that intact astrocyte signaling may be essential to glucoregulatory control over gastric motility.
Radial glial cells (RGCs) are progenitors that are derived from NE cells, reside in the ventricular zone (VZ) and form bipolar radial fibres between the ventricular and pial surfaces in the cortex (FIG. 1). RGCs display features of glia, which include serving as scaffolds for migrating neurons, expressing glial markers such as glial fibrillary acidic protein (GFAP) and astrocyte-specific glutamate transporter (GLAST; also known as SLC1A3), and giving rise to astrocytes9–11. More-recent studies have shown that RGCs can produce neurons and, subsequently, astrocytes and oligodendrocytes9,10,12. Conceptually, the radial unit hypothesis postulates that the cortex is assembled from radial progenitor units that consist of proliferative RGCs and more differentiated daughter cells, including neurons, which ultimately migrate radially along RGC fibres to form the characteristic six-layered cortical structure, from the inside out10,11,13 (FIG. 1).